Nodules don't flatten with skincare. They sit too deep for face masks, serums, or targeted spot care to reach, and picking or pressing only makes them more inflamed and more likely to scar. The fastest, safest way to calm a nodule is in a dermatologist's office. A cortisone injection can bring one down within a day or two, and for ongoing nodular acne, derms have prescription options like spironolactone, oral antibiotics, or isotretinoin depending on your situation and history. In the meantime, keep the area clean, skip the harsh scrubs, don't touch it, and book the appointment. This is best managed by a board-certified dermatologist.